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Use of primary and secondary stove/fuel types as categorical variables is a somewhat crude representation of exposures within a home, because it does not account for relative frequency of use or for other fuel-using devices, such as lamps or additional stoves.
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Adequate quantification of exposure of the plant community is often lacking, including poor representation of exposure scenarios that adequately mimic spray drift.
A reduction of the temporal resolution in feeding assays is likely to improve the representation of exposure in the field, but it is likely to be accompanied by increased variability in results.
However, we feel that this method does offer a fairly good representation of exposure.
Furthermore, a large inventory of possible ACEs was examined in this study to gain an accurate representation of exposure to ACEs in youth.
This study relied on cross-sectional exposure and outcome measures, and was therefore subject to the classical limitations of cross-sectional design with respect to temporality, prevalent events, and representation of exposure windows.
This modest decrease in power, due to the re-allocation of some subjects from the original exposure sampling zones to post-hoc exposure zones, is justifiable as the post-hoc zones were a better representation of exposure during the study period.
Further developments to satellite retrievals and simulated aerosol profiles will continue to allow improved representation of global exposures to PM2.5.
The HUAS-based sampling weights are thereby likely to approach a "real-time" representation of the exposures, case disease, and outcomes, thus increasing the validity of the weighted regression analyses.
It is not possible to fully assess whether this particular site provides better representation of population exposures to certain local sources (e.g., traffic) compared with other local sources (e.g., residual oil).
For markers with poor reproducibility within subject, having multiple measures of exposure may give a more accurate representation of average exposure and confer greater power for detecting an association with preterm birth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com