This relationship was more pronounced when IP mothers were compared to NT mothers where IP mothers had 10.3% representation of Bx32 compared to the 0.7% in NT mothers (P = 0.014; OR = 17.2).
Transmitting mothers had significantly lower representation of Bx20 compared to NT mothers (1.35% vs. 10%; P = 0.02; OR = 0.1) and TR mothers had significantly higher representation of Bx32 compared to NT mothers (5.4% vs. 0.7%; P = 0.04; OR = 8.5).
Regional distribution varied with higher representation of Eastern compared to Western Europe (10% and 6% of 968,910 and 1,987,904 live births, respectively; OR 1.80; 95% CI 1.78-1.81) and lower compared to Northern and Southern European countries (12% and 18% of 1,357,998 and 1,258,047; OR 0.52; 95% CI 0.51-0.52 and 0.84; 0.83-0.84, respectively) in the SES.
In this study, we observed a preferential engagement of RR units with the reward representation of centrifugal compared to centripetal replayed spatial content, while we did not detect a preference for RR units for the reward representation of reverse compared to forward replayed spatial content.
In addition, NT mothers had higher representation of KIR2DL2 compared to TR mothers which appears to be independent of whether transmission was IP or IU (Table S1).
A trend however was noted in the infant group where IP infants had approximately 20% lower representation of KIR3DL1+Bw480Ile compared to EU infants (P = 0.062; OR = 0.41) (Table S4), however this trend was lost post MVL adjustment (Table 2) and upon NVP stratification (data not shown).
However, given the almost 9-fold higher representation of Holocene compared to Pleistocene sequences, the statistics should be treated with caution.
For regions with associated transcripts, gene ontology (GO) annotations were obtained and an analysis was performed for over/under representation of terms compared to a whole genome background.
The result from the gene search interface is the informatively named gene signature hits in which the queried gene is found, along with numerical ranking information in uniform representation and explicit designation of compared sample groups.
Adaptations for case-cohort data deal with the over-representation of cases compared to the original cohort design.
