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An allelic imbalance between mutant and wild-type RET may represent the decisive step of tumorigenesis for MTC and pheochromocytoma [ 11- 15].
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That, of course, does not stop people spotting them immediately.In the last few months of 2007, much of the political class has confidently predicted the end of Labour's long imperium though there is disagreement over which of the superabundant governmental calamities represented the decisive moment.
The rediscovery of crown ethers (CR) and their role as phase-transfer catalysts (PTC) (Pedersen, C., 1967) [36] represented the decisive impulse in the theoretical and practical conformational study of cyclic and acyclic PEO chains, as such and derivatized.
c Axial T2-weighted fast spin-echo image (6006/110) display no differences in signal intensity between left and right postero-lateral aspect, and it represents the decisive sequence confirming the mispositioned endorectal coil.
Leaders are of particular importance in this construct, because their attention towards stressed employees represents the decisive lever in preventing productivity losses and costs caused by stress-related illness.
Moreover, strong HER2 expression represents the decisive molecular basis for tumour therapy targeted at the same receptor.
Contact cues, signals that are bound to the surface of the sender's body, represent the final decisive hurdle in the initiation of mating behaviour [5] and have been described to exist in many insect species [6], [7] as well as in crustaceans [8].
More importantly, the outcome of the fighting on the eastern front would have a direct bearing on the number of additional troops that Germany could deploy on the western front and could represent the margin for a decisive victory in the west.
Ultrasonographically guided punctures of the liver represent a decisive tool in the diagnosis of many diseases of the liver.
CDC also reported that MSM accounted for the majority of new gonorrhea and syphilis cases, and the report prompted the director of CDC's National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention to declare the findings represent "a decisive moment for the nation"—a turning point in how we must approach our country's STD treatment infrastructure.
In Alzheimer's disease (AD), within the two major classes of biomarkers now identified, biomarkers of disease state (i.e., biomarkers of amyloid β [A β] accumulation) and biomarkers of disease stage (i.e., biomarkers of neuronal injury), amyloid-PET, and FDG-PET imaging represent critical and decisive tools.
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