The development of resistance to chemotherapy represents significant obstacles to treatment of malignancies relying on conventional cytotoxic agents.
But there will still be significant obstacles.
Trips to Dublin and Twickenham present significant obstacles, but not psychological barriers.
Shaded cells represent significant p-values.
Downregulaton of BRCA1 results in increased p53 and p21 expression [31], which may represent a significant obstacle to tumorigenesis that can be overcome by somatic mutation of the p53 gene.
However, crowded NMR spectra represent a significant obstacle for the complete resolution of these anisotropic parameters.
However, in vivo delivery issues still represent a significant obstacle for widespread clinical applications.
Does climate/seasonality represent a significant obstacle for revegetation?
As the vemurafenib example shows, the rigid data requirements of the G-BA, together with the lack of methodological guidance, also represent a significant obstacle to obtaining a superior benefit rating in a re-assessment, even if new data are submitted.
These side effects represent a significant obstacle to the effective treatment of cancer [ 3, 4].
