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Age-specific breast cancer incidence in the BRCA1 and BRCA2 populations [ 2] was weighted to represent mutation frequency at the BCCA (59% BRCA1 and 41% BRCA2; Table 1).
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The 16 changes in a single subject represent a mutation frequency of 1.4% of the total sequenced bases.
To represent mutations, we start a new haplotype at a population frequency q0=1×10−3, at the establishment time t a, rescaling the frequencies of other haplotypes accordingly.
R A variable representing the mutation frequency above background.
One acral melanoma contained an exon 17 (D820Y) mutation, representing a mutation frequency of 6% within this subtype.
In four genes (SPTLC1, RAB7, WNK1/HSN2, NTRK1), we identified disease-causing mutations in 19 index patients representing a mutation frequency of 19%.
The MSI- and mutation-frequencies of the analyzed genes are presented in Table 1, and a heat map representing mutation data for all samples is shown in Figure 1.
μ A variable representing the background mutation frequency of the tissue.
Every value in the graph represents the virus mutation frequency in a different animal faecal sample after 18 days of treatment.
The probable contribution of each of the nominated genes to the pathogenesis of BEN (according to their mutation frequency) is represented in Figure 1.
He warns that various chemicals, including groups represented by pesticides, "can raise the mutation frequency as much as radiation," and he says, "As yet far too little is known of the extent to which our genes, under modern conditions of exposure to unusual chemicals, are being subjected to such mutagenic influences".
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