Sentence examples for represent major obstacles from inspiring English sources
Multidrug resistance (MDR) and drug transporter P-glycoprotein (P-gp) represent major obstacles in cancer chemotherapy.
The study area described here lies in a mountainous region, and topographic effects in terms of the earth's curvature, mountain shadow, and clouds represent major obstacles that need to be taken into account (Itten and Meyer 1993).
OP is mostly used for composting and production of animal feed; nevertheless, the high oil content, phenolic compounds and fiber contents in addition to its low protein content represent major obstacles for both applications.
However, prohibitively high manufacturing costs, unstable production in run-to-run and wafer-to-wafer, inadequate light uniformity, and inferior color rendering index represent major obstacles to GaN-based LED as a main light source in the future.
However, the extreme reactivity of this aldehyde, as well as its insolubility in water, a limiting factor for drug bioavailability, and its rapid degradation by specific enzymes represent major obstacles to its possible in vivo application.
Despite substantial improvements in intra- and postoperative management of extended hemihepatectomy as the curative option for treatment of central liver tumors, the high morbidity and mortality rates accompanying the procedure still represent major obstacles.
For example, misunderstandings about the importance of diabetes and personal risk factors, and patients' lack of awareness, psychological factors or practical obstacles, can represent major barriers to attending screening.
The obstacles to research progress represent major challenge areas for obtaining health improvements from the basic sciences in its field.
These are associated with parasite immune evasion and represent a major obstacle for subunit vaccine design.
Substantial and highly variable placebo response rates represent a major obstacle to antidepressant development in major depressive disorder (MDD).
However, data requirements, particularly for the more complex urban models, represent a major obstacle to their employment.
