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FGFR gene alterations represent a target for treatment in clinical trials of urothelial carcinoma (UC).
They represent a target for attempts to find disease-associated genetic variants and elucidation of mechanisms.
These results suggest that the receptor-G protein interface may represent a target for receptor antagonist drugs.
Finally, anti-diabetes drugs can affect cancer cells, and in some cases represent a target for cancer therapies too.
Oxidative and cytotoxic damage play an important role in cerebral ischemic pathogenesis and may represent a target for treatment.
Accumulated evidences have established that inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment.
Plasmodium falciparum, the causative agent of malaria, is sensitive to oxidative stress and therefore the family of antioxidant enzymes, peroxiredoxins (Prxs) represent a target for antimalarial drug design.
Although the mechanism for the increase of soluble E-selectin remains to be elucidated, the upregulation of soluble E-selectin indicates neutrophil activation, and its inhibition may represent a target for reducing the inflammatory response associated with CPB.
By using a 14-residue fragment of CCR5 Nt containing two TYS residues, we recently showed that CCR5 Nt binds gp120 through a conserved region specific for TYS moieties and suggested that this site may represent a target for inhibitors and probes of HIV-1 entry.
Thus, it can ideally represent a target for a treatment aimed at reducing tumor growth.
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PTEN appears to be relevant against cancer progression and represents a target for somatic cancer inactivation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com