"represent a significant problem" is a perfectly correct and usable part of a sentence in written English.
You could use it in a variety of situations. For example, "The decrease in community involvement has come to represent a significant problem in many neighborhoods."
Patients who leave before being seen by a physician represent a significant problem for many emergency departments (EDs).
Description and analysis of acoustic waves in ducts with a region containing temperature-inhomogeneous fluid represent a significant problem of scientific and practical interest.
Clearly, so-called off-target gene silencing could represent a significant problem, resulting in RNAi adversely targeting multiple genes simultaneously.
The fungal infections represent a significant problem to health and are one of the causes of morbidity and mortality in the world.
With an ageing population and a rising burden of chronic disease, AKI and ensuing CKD will continue to represent a significant problem faced by many specialties.
Transient and self-limiting CARPA reactions occurred in 7.4% (2/27) of patients and do not represent a significant problem with the current mode of administration.
Indeed, the traditional use of this family of highly nephrotoxic and carcinogenic herbs represents a significant problem for global public health.
"This represents a significant problem.
Driver distraction represents a significant problem in the public transport sector.
Currently, immune-based approached are most commonly applied, although moderate selectivity of antibodies represents a significant problem.
Target site inaccessibility represents a significant problem for fluorescent in situ hybridisation (FISH) of 16S rRNA oligonucleotide probes.
