In this context, the spatial and the temporal rainfall variability represents a significant issue, especially for basins in which the rainfall field cannot be approximated through the use of a single station.
This represents a significant issue for effective individual and group situational awareness and would have impacted upon shared mental models of the situation, resources required, and decisions to be made (Section 3).
However, it is important to note that the role of other no-BCR-ABL abnormalities on the expression signatures of genes evaluated in this protocol represents a significant issue to explore, and therefore its effect on the prognosis value of these genes should be assessed.
It is likely that PLA will represent a significant conservation issue due to its instability.
However, the rates remain at a high level and still represent a significant health issue that requires regular monitoring.
Being one of the most known and used NPS, synthetic cannabinoids may represent a significant health issue.
The shortage of blood supply and the ever-growing demand for blood transfusion represent a significant emerging issue in transfusion medicine.
Thus, based on the results of our meta-analysis, adverse events do not seem to represent a significant safety issue and an obstacle to the acceptability of the ID vaccine.
