Sentence examples for represent a rationale from inspiring English sources

In conclusion, we showed that SHH pathway could be involved in the self-renewal, proliferation, drug resistance and tumorigenic of tumorsphere cells and suggest that strategies aimed at inhibiting SHH pathways represent a rationale therapeutic approach to target gastric CSCs.

Such radiation-induced activation of EGFR-dependent processes may represent a rationale for combined treatment with radiation and EGFR inhibitors.

This finding is in particular intriguing as it may represent a rationale for a targeted therapy with specific tyrosine kinase inhibitors such as c-KIT blockers in mucosal melanomas.

The effects of creatine supplementation on muscle performance and protein metabolism and, possibly, muscle integrity may represent a rationale for its potential use to prevent or treat muscle disorders.

The coexistence of high- and low-molecular-weight surfactants, for instance, in addition to the role played by CO2, can represent a rationale to interpret the debate over the foam-promoting role of robusta coffee in espresso blending or the peculiar foam adhesion observed in pure robusta espresso.

The observation that even healthy subjects experience deterioration in cardiac function and energy metabolism in the context of sustained hypoxia represents a rationale for this pathological sequence.

These results suggest that the PKA pathway could be activated in human cancer cells with intrinsic resistance to selective MEK inhibitors and represents a rationale for the investigation of combining MEK and PKA inhibitors in cancer treatment.

Thus, these results represent a strong rationale for follow-up studies addressing combination therapies of Danusertib with IM and potentially, 2nd generation tyrosine kinase inhibitors such as Nilotinib, Dasatinib and Bosutinib in order to improve therapeutic effects in BCR-ABL-positive leukemias.

These rankings represent a systematic rationale for informing chemical prioritization decisions.

These data represent a strong rationale for testing PLD in the first line treatment of ovarian cancer.

Therefore, hepatic TSC22D4 activity may represent a molecular rationale for peripheral energy deprivation in subjects with metabolic wasting diseases, including cancer cachexia.