Sentence examples for represent a checkpoint from inspiring English sources

Therefore, it has been proposed that autophagy may represent a checkpoint for maintaining homeostasis of miRNA populations [ 76], and so it interesting to speculate that inhibition of SnRK1.2 by the geminivirus AC2/C2 proteins may have wide-reaching effects on both RNA silencing and autophagy.

One such pathway involves the c-Myc gene, which encodes a helix-loop-helix transcription factor with several functions including inducing cell cycle progression and which represents a checkpoint in cell homeostasis.

Of note, knockdown of TBL1 in both human and murine pancreatic cancer cells significantly impaired tumor cell invasiveness (Supplementary Fig S4), overall suggesting that TBL1 represents a checkpoint in the tumorigenic program of pancreatic tumor cells.

Alternatively, it may represent an additional checkpoint utilized by cells of the innate immune system as they access pre-armed functions.

Phosphorylation and dephosphorylation of the C-terminal domain (CTD) of RNA polymerase II (Pol II) represent a critical regulatory checkpoint for transcription.

In addition, the AMPK-p53 pathway may represent a cell cycle checkpoint in response to energy limitation.

These observations define the minimal DNA requirements for checkpoint activation and suggest that primed ssDNA represents a common checkpoint activating-structure formed following many types of damage.

This represents a first checkpoint in early B cell development.

This particular stage represents a critical checkpoint in T cell development that is known as β-selection.

Thus, LasR represents a central checkpoint with the highest degree of interconnection in the network [ 10, 11].

3 The T-cell compartment of adaptive immunity is regulated at multiple levels to prevent inappropriate activation (ie, autoimmunity) and the inhibitory activity exerted by CTLA-4 represents a crucial checkpoint at the periphery.