First, chromatin is repositioned away from the nuclear periphery in response to global acetylation.
Indeed, some genes appear to reposition away from territories upon transcriptional activation [33], [34], [35].
The integration site at MMU3A3 is also repositioned away from the nuclear periphery and further away from the nearest gene than any other investigated mouse integration site.
The HIV integration locus HeLa18q22.3 nicely fits in such a model since it repositioned away from the nuclear border, decondensed and lies in a gene free part of a gene poor chromosome (Table 2).
In almost every area, he is repositioning Labour away from statism and Gordon Brown's belief in centralised micro-management.
The company in July laid off over 100 people based in its Berlin HQ — we actually heard closer to 150 at the time — a consequence, it says, of repositioning itself away from flash sales.
This seemingly contrasts with Partensky et al. [41] who argue that yeast RSC and human ISWI containing ACF complexes are as efficient in repositioning nucleosomes away from the initial position on DNAs with widely divergent octamer affinities and nucleosome breathing dynamics.
Repositioning oneself away from the expert to someone who supports the development of knowledge is challenging, particularly in contexts where the overwhelming experiences of education have been didactic and 'top-down' as for the facilitators in South Africa [ 13, 18].
By analogy, during BAK activation, the outer α1 helix repositions away from the protein core exposing the α6 helix, which together with the α5 helix resembles the central hairpin of the PFTs.
Shares of the Detroit company, already struggling to reposition itself as consumers shift away from pickup trucks and sport-utility vehicles toward better fuel efficiency, slumped 7.6%.
