Sentence examples for repositioning approach from inspiring English sources
While the safety assessment is based on drug label information, the drug repositioning approach may involve different formulations and changes in dosage that need to be considered in different patient populations.
Considering the limited and toxic therapeutic arsenal available for visceral leishmaniasis (VL), the drug repositioning approach could represent a promising tool to the introduction of alternative therapies.
A series of chloroquine (CQ) analogs were designed and synthesized in a repositioning approach to develop compounds with high anti-breast cancer property.
The repositioning approach is therefore particularly useful to speed up the discovery of new drugs with potential therapeutic effects for human inflammatory diseases.
In particular, repositioning approaches may find suitable drug candidates for disease targets with low-frequency mutations.
However, how to utilize this knowledge and effectively conduct and implement computational drug repositioning approaches for rare disease therapies is still an open issue.
Based on the analysis, ocean carriers seem to be unwilling to revise their actual container management strategies focused on maritime repositioning, disregarding the potential and importance of intermodal repositioning approaches based on market collaboration.
In this regard, compounds that have passed through phases II or III in the drug discovery pipeline but never made it to the market due to efficacy issues bear great potential for drug repositioning approaches.
Because of the complexity of the inflammatory response, the identification of new therapeutic compounds for inflammatory conditions is especially suited to repositioning approaches.
These timelines are much shorter than the 13.5 year average currently reported for new drugs [ 5] and highlight the efficiency of repositioning approaches.
In addition to the original cMap approach, multiple other methods have been developed based on cMap data for new drug repositioning approaches [ 23- 28] or improving the performance of exist cMap [ 29- 31].
