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Considered together with existing information on more complex inherited variant regions, and reports of de novo variants associated with autism, these data support the presence of different subgroups of CNV in the genome which may have originated through different mechanisms.
However, to our knowledge, no reports of de novo whole-genome sequencing have been published for any polyploid species.
When an additional case from our research group was added, there were eight total case reports of de novo anti-GBM disease in pregnancy.
39 Based on our report and the two recent additional reports of de novo dominant mutations, this mode of mutation and pathogenesis, may be more common than initially appreciated.
There were no reports of de novo dysphagia or bloating at 12-month follow-up; one patient reported de novo excess flatulence (from score 0 at screening on PPIs to score 3 off PPIs at 12-month follow-up).
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These results were concurrent with a previously reported study of de novo transcriptome analysis in tuberous root of sweet potato [ 28].
This also applies to the reports of de-worming properties of herbal preparations that have either Nordic origins, or a long history of use in this region (for some historical background, see [ 27]).
This is also the first report of de novo biosynthesis of resokaempferol and fisetin in yeast.
To the best of our knowledge, this is the first report of de novo CNVs in cloned animals including dogs generated by SCNT technology.
To our knowledge, this is the first report of de novo CNVs in the cloned dogs which were generated by somatic cell nuclear transfer technology.
Literature regarding hemodialysis in pregnancy has expanded since the first report of de novo anti-GBM disease in pregnancy, in 1986 [ 10].
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CEO of Professional Science Editing for Scientists @ prosciediting.com