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This is the second report of familial ONs with only one previous report of a Swiss family in which a man was affected in the first generation and all women but none of the men were affected in the second generation [14].
Also noteworthy is the report of familial presence of parasomnia.
There have been reports of familial occurrence, but no definitive hereditary pattern has been established [3, 13, 14, 15].
There is at least one report of familial sexual headache (four sisters suffering from orgasmic headache with "vascular features") [48], but this does not seem enough to support a genetic basis of the disorder.
There is growing evidence to suggest a genetic predisposition to HL, based on many reports of familial aggregation of the disease [4] [6], including a twin study [7].
This is the first report of familial BL outside Africa.
However, reports of familial MCD are scarce and no causal gene has been identified yet.
More reports of familial MCD are needed in order to understand the disease transmission pattern.
To our knowledge, there are no previous reports of familial presentation of TIN in association with PBC.
Reports of familial cases and parallelism in identical twins imply a genetic contribution to the pathophysiology [ 4].
Although PBC could be a familial disorder, there have been no previous reports of familial chronic TIN in association with PBC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com