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Substantive contributions to the design, conduct, interpretation and reporting of a clinical trial are recognised through the granting of authorship on the final trial report.
267 Substantive contributions to the design, conduct, interpretation, and reporting of a clinical trial are recognised through the granting of authorship on the final trial report.
Clearly, it cannot be concluded from a doctor's reporting of a clinical practice in her/his setting, that this practice is used all the time for every patient who needs it: self-reports mainly provide information regarding clinicians' knowledge of guideline recommendations, but they are subject to bias – overestimation – and should not be used as the sole measure of guideline adherence [ 27].
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In the two recent reports of a clinical trial of personal vaccines for late stage melanoma7,8 there are several important conclusions.
Other potential limitations of our study need to be addressed, such as the self-reporting of a clinical diagnosis or the use of medication to define an incident case of depression.
In this connection we would like to emphasize that in the original report of a clinical trial it will be more informative not only to report the overall ES but also the control event rates for different definitions of response in a tabular format [27].
Most cases of hypoglycemia described in ICU trials are of short duration (< 2 hours) and exclusively biology-based with no report of a clinical sign of severity [ 42].
Another 18 had a report of a clinical symptom potentially related to prolactin (five of whom also had a report of hyperprolactinemia).
There was a report of a clinical trial using adipose tissue-derived MSCs for the treatment of four AD patients, showing decreased clinical scores and inflammatory responses.
The first report of a clinical trial of the combination of an HDACi with radiotherapy was reported by the group of Flatmark (Ree et al. 2010).
Reports of a clinical benefit from gefitinib maintenance therapy after first-line platinum-based chemotherapy in clinical trials caused great excitement among both oncologists and patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com