Our findings are consistent with recent studies reporting negative impacts of Cre and/or tamoxifen administration on animal physiology (Bersell et al., 2013).
The four items with the highest proportion of pregnant women reporting negative impacts were "taste worse", "painful aching", "uncomfortable to eat" and "self-conscious"; all of these items are within the domains of functional limitation, physical pain and psychological discomfort.
Most studies reporting negative impacts of prenatal Ramadan fasting were conducted without access to reported fasting data, so have been unable to examine the potential role of duration of exposure nor had they accurately recorded the timing of exposure to Ramadan using ultrasound data or other objective measures [ 2, 11, 12] with the exception of a substudy included in one of the studies [ 2].
Self-perceived pornography addiction (SPPA) has increasingly emerged as a concept in research and popular culture, and commentators warn of the reported negative impact that it has.
The most frequently reported negative impact on the local ecosystem is decreased diversity and decreased abundance of local species.
In four studies, a range between 5% and 18% of athletes reported negative impact of oral health or trauma on performance.
The association of cardiovascular events with deterioration of kidney function comes in agreement with the reported negative impact of acute kidney injury on cardiovascular outcomes in patients with pre-existing cardiac disease [ 19– 219.
45 Further, the presence of CD4+CD25+FOXP3+ T regulatory (Treg) cells in tumors has a reported negative impact on survival, suggesting that these cells might suppress host anti-tumor immunity.
The high reported negative impact on MD-specific domains such as independence, personal affairs and do for others suggests that the condition-specific measure will be more sensitive than a generic QoL measure, as it investigates aspects of life that are particularly impacted by MD and these are not included in many, if any, generic measures.
Participants reported negative impact on their life opportunities, which in two thirds of cases were related to employment, such as giving up or not being able to be employed in their favorite job, losing the chance for promotion, choosing a less stressful job and even getting fired.
