Exact(2)
Secondly, algorithms such as MotifX or PhosphoMotif Finder analyze the sequence environment of post-translational modification sites [ 69, 70], thereby reporting enrichment of certain amino acid motifs which can help to identify the modifying enzyme.
To allow meaningful comparison of enrichment methods and experiments that employ them, and to rationally decide which technologies are most suitable when designing a research project, it is important that an objective set of descriptive metrics are defined and then widely used when reporting enrichment datasets.
Similar(58)
This is supported by the reported enrichment of GWAS-SNPs which are themselves enriched for eSNPs (6)—within GWAS-SNPs which pseudogenes (69).
The same trend was observed by Shin and Lee (2010), who reported enrichment factors for benzene and toluene of −0.58 and −0.41‰, respectively.
In Additional files (cf. Additional file 2: Tables S1, S3), we also report enrichment at several cutoff values (5, 10, 20, and 30%%), as well as the results corresponding to 31NN and 51NN.
However, this study varied in its experimental approach (e.g., use of one antibody, microarray design and data analysis parameters) and the reported enrichment analysis was based on a comparison between the presence of the CACGTG motif and all other E-box variants grouped together as CANNTG.
This corroborates the previously reported enrichment of very-long chain fatty acids in myelin sphingolipids.
Others have also reported enrichment of cells with the CD44+/CD24- phenotype in basal-like breast tumors [ 14].
All reported enrichment p-values are FDR-adjusted using the Benjamini Hochberg method (Benjamini and Hochberg, 1995).
We report enrichment scores of 1.3 or greater (corresponding to log2 = 0.05 cutoff value) for categories with at least 5 genes in the result set.
A more recent study reported enrichment of YCAY (Y is C/U) in the mRNAs bound to Khd1p (Wolf et al. 2010).
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