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The study also found a higher but non-significant percentage of patients treated with Prozac reported troublesome side effects, and there was a trend toward greater treatment interruption for adverse effects in the Prozac group.
Twenty-four per cent (n=1659) of the cohort reported troublesome NSAP at follow-up (2010).
Of those participants who had reflux symptoms below the threshold for symptom-defined GERD, 40.0% (142/355) reported troublesome symptoms.
The relation of disability to urinary incontinence was at least as strong, with both men and women who reported troublesome urinary incontinence being more likely to report each disability (except, for women, not getting enough food).
Of 9 patients who reported troublesome regurgitation after being on high-dose PPI therapy for six months, 67% (6/9, 95% CI, 35 to 88) reported no troublesome regurgitation six months following TF while off PPIs.
When participants were grouped into (1) those with experience of first-line therapy only (n=61) and (2) those with experience of second and subsequent chemotherapies (n=141), the proportions who reported troublesome side effects changed.
Similar(53)
Nocturnal cough is often used as a hallmark of asthma as children with asthma often report troublesome nocturnal cough [ 55].
The proportion of individuals reporting troublesome symptoms increased as reflux symptom frequency and severity approached the threshold for symptom-defined GERD, and this was associated with concomitant decreases in all HRQoL measures.
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Among these were compounds that were also reported as troublesome by other workers using alternative multi-residue methods, e.g. asulam [ 30].
Patients who reported daily troublesome regurgitation and/or atypical symptoms on daily PPIs underwent esophagogastroduodenoscopy (EGD) and 48-hr pH monitoring after a 'wash out' period of at least seven days.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com