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Meta-analysis of heterogeneously reported trials assessing change from baseline.
Even though the number has been substantially growing for the past years, the finished and reported trials are limited.
Finally, several recently reported trials of neoadjuvant therapy incorporating newer agents such as taxanes in sequence with anthracycline-containing regimens have shown further increases in pCR rates.
The goal of this systematic review was to determine the benefits and risks of tight glycemic control in ICU patients and to explain the differences in outcomes among reported trials.
Future low risk of bias, properly powered, and comprehensively reported trials are warranted to evaluate the efficacy of exercise on injury prevention.
If one only reported trials that resulted in heads 5 or more times, others would have a deeply distorted understanding of the coin's behavior, mistakenly concluding a tendency towards "heads" that did not actually exist.
Poorly designed and reported trials usually exaggerate the treatment effects which will mislead clinical decision making.
Non-communicable diseases represent 48% of the global burden of disease but only 14% of reported trials.
There are three ongoing or not yet reported trials.
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However, few missing records or items were reported and the validity of self-reported trials was confirmed in a large trial.
However, literature review showed that questionnaire design and respondent motivation have more influence on recall bias than period of recall, few missing records or items reported, and the validity of self-reported trials was confirmed in a large trial.
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