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Deregulation of microRNAs has been reported to modulate normal cell growth and differentiation, potentially leading to a variety of disorders, including cancer [ 6, 7].
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Finally, the NMD pathway has also been reported to modulate the expression of several normal genes by mechanisms involving the presence of an upstream open reading frame or an intron in the 3' untranslated region, both of which are predicted to elicit NMD [12], [13].
A few ISGs have been reported to modulate this pathway.
Light deprivation (LD) has been reported to modulate M1 excitability in control subjects (CS).
Quercetin was reported to modulate CYP isoenzymes and P-glycoprotein (Pgp), a drug efflux transporter.
To our knowledge, neither niclosamide nor perhexiline have been previously reported to modulate autophagy.
This powerful oxidant has been reported to modulate cellular functions through the nitration of tyrosine residues.
Oxidative stress has been reported to modulate the signal transduction pathways in lymphocytes [17].
Central NO is reported to modulate the secretion of vasopressin.
Interestingly, oxidative stress has been reported to modulate DES1 activity.
AMBRA1 was reported to modulate the BECN1-PIK3C3 complex.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com