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Among them, only Cluster 2-related models have been successful while no Cluster 1-related knockout mouse was so far reported to develop a PPGL.
Transgenic mice were also reported to develop a spontaneous neurological disease in the absence of PrPsc when preferentially expressing a transmembrane form of prion protein (PrPCtm) [58], [59], which would imply that CtmPrP is a key component in the pathway of neurodegeneration as in Gerstmann Sträussler-Scheinker syndrome.
Both types of mice have been reported to develop a mild form of OA in the knees.
Compatible with a role of Flt3-ITD signaling in lineage determination, two different knockin mouse models of Flt3-ITD have been reported to develop a myeloproliferative phenotype exclusively (Lee et al., 2007; Li et al., 2008).
Rabbits have also been reported to develop a sensory neuropathy following immunization with GD1a and GM1 and the findings correspond well with pathological findings for human AMAN; however, this model fails to show demyelination with respect to AIDP [ 67].
A number of tumours and tumour cell lines have also been reported to develop a permanent and selective IFN- γ insensitivity, such as testicular germ cell tumours, RCC cell line, basal cell carcinoma of the skin and human lung adenocarcinoma cell lines (Kooy et al, 1998; Dovhey et al, 2000; Nagao et al, 2000; Schweyer et al, 2002, 2003; Dunn et al, 2005b).
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Human diploid fibroblasts cultured under normal conditions have been reported to develop an irreversible cell cycle arrest, referred to as replicative senescence (Serrano and Blasco 2001).
met-2 single mutants are reported to develop an Mrt germline defect over 18−24 successive generations (Andersen and Horvitz 2007; Bessler et al. 2010).
There is also a strong relationship between adolescent attention deficit hyperactivity disorder (ADHD) and adult alcohol dependence [Edwards and Kendler, 2012] with at least 30% of subjects with ADHD reported to develop an alcohol use disorder [Wilens et al., 2011; Tuithof et al., 2012].
Memory B-cells are reported to develop at a low level following mumps infection, which may be an independent risk factor for infection on exposure after vaccination.
Furthermore, most recurrences originating from tumor thrombus have been reported to develop within a year of surgery [4], unlike this case in which recurrence occurred 50 months after primary hepatectomy.
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