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Protic ionic liquids based on substitute amines and carboxilate anions were reported to be selective to methane/carbon dioxide separation.
CoMFA (Comparative Molecular Field Analysis) and de novo ligand design using LeapFrog (LF) studies were performed on pyridazine analogs, reported to be selective and non-competitive inhibitors of PTP1B.
Rapid inhibitory and readily reversible effects of allatostatin were previously reported to be selective for AlstR-expressing neurones.
G15, a substance from a compound library, was reported to be selective for GPR30 and inhibited signal transduction of GPR30 [ 14].
As TRAIL is reported to be selective in inducing apoptosis in malignant cells, although sparing healthy cells (Ashkenazi, 2008), numerous proapoptotic receptor agonists have been developed that include recombinant TRAIL and monoclonal agonistic antibodies against DR4 and DR5.
On the contrary, Ro 32-0432 in the 5 50 nM concentration range (which has been reported to be selective for conventional PKC isoforms [ 12]) had no effect per se on the response of human PMNs to TTN (Fig. 2).
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AKβ-BA (4) has also been shown to enhance the release of arachidonic acid via cytosolic phospholipase A2 [74] and has been reported to be a selective inhibitor of COX-1 [66].
In addition to DYRK1A inhibition, harmine has been reported to be a selective inhibitor of monoamine oxidase (MAO-A) [12].
Torin was reported to be highly selective [ 53].
ATF3 is reported to be a selective marker of cell damage following nerve injury [ 23].
WIN17317-3 (Fig. 1) was first reported to be a selective voltage-gated potassium channel blocker.
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