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The group reported subtle differences between the structure of the metal-binding protein TTHA1718 found in bacterial cells and the structure of the protein in vitro.
Previous behavioral studies reported subtle working memory impairment in JME patients (Wandschneider et al., 2012).
These relatively rare exposures have been evaluated in small studies that have reported subtle effects.
Two cytogenetic studies previously reported subtle heteromorphisms of the smallest chromosome pair that were consistent with ZW segregation (Haschuka and Brunst, 1965; Cuny and Malacinski, 1985).
For example, Mirelman et al. (2011) reported subtle gait changes among asymptomatic carriers of LRRK2 mutation with quantified gait analyses under challenged conditions.
Our results from this large sample generally differ from those of a small case series studying depuration, which reported subtle decreases in concentration over the course of lactation among eight women (Hooper et al. 2007).
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Studies reporting significant shifts in plant gene expression in response to Epichloë are mainly conducted with artificial fungus-plant combinations and using fungal removal and/or inoculation manipulations26,27,30, while studies reporting subtle plant responses have been conducted with E+ plant lines with long symbiotic histories and naturally endophyte-free E− plants31.
Studies report subtle differences in 18F-FDG uptake between patients and controls [14, 15, 18, 50].
Recent brain autopsy studies report subtle microscopic vascular and nonvascular white matter abnormalities in patients with type 2 diabetes (10, 11).
We here report subtle alterations of the RNFL and the total macular thickness as well as a marked reduction in the INL, suggesting neurodegeneration beyond the motor system in this disease.
While some studies report subtle differences in the Healthy Eating Index and improvements in health and reduced complications of type 2 diabetes [ 35], other studies report larger differences in diet quality, in association with changes in blood pressure and other measures of cardiometabolic disease, including cholesterol [ 36, 37].
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