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Moreover, we docked rofecoxib, a selective COX-2 inhibitor and observed that the average root-mean-square deviation between the best reported pose for rofecoxib and the native compound ibuprofen was 7 angstroms, although its docking score was −7.2 kcal/mol (data not shown).
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Additionally, the issue of selective outcome reporting posed a challenge as protocols or trial registers were unavailable for the majority of studies.
These findings are consistent with results from studies in Benin, Kenya, Malawi and Tanzania, where performance reporting posed challenges in the health sectors [ 18, 20, 22, 25].
Imprecision in how workarounds are defined and reported poses challenges for researchers and those who would synthesise the evidence.
Given that California is a best-case scenario* compared to other states (and, of course, countries) far more dependent on coal, Long's piece and the underlying report pose a strong challenge to those calling for a "deploy, deploy, deploy" approach to cutting climate risks.
However the recommendations made in Lord Browne's report pose a grave risk to UK industry.
The Starting Strong review and both its reports pose their own critical questions and provoke in us others.
Salas doesn't completely agree with Cornelio about the overall urgency that some UFO reports pose.
Increased accumulation of pesticide residues in the food chain and drinking water have been reported to pose serious human health hazards (Akan et al. 2013; Agbeve et al. 2014).
However, elevated concentrations in sediments and sufficient accumulations in the biota have also been reported to pose a great hazard to freshwater ecosystems and toxicological risk for humans (Chapman and Kimstach 2006; Dachs and Mejanelle 2010; Ray and McCormick-Ray 2014).
However, revision spine surgery is challenging and has been reported to pose a greater risk for complications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com