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The reported overriding rate varied from 40%to96%6% and the alerts most often overridden concerned orders renewals, interaction with topical drugs, and uncertain allergies.
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Our findings were consistent with those of previous studies, which reported override rates ranging from 40%to>8080% with CDS for nephrotoxic or renally cleared medications in various settings [ 7, 17, 21].
Caffeine was the first drug reported to override checkpoints and several reports described caffeine inhibition of Rad3 [31], and Rad-related kinases ATM or ATR in mammalian cells [40] [42].
Furthermore, poverty and need for money was reported to override need for protection.
MAD2ΔC has been reported to override the function of MAD2, therefore, it is regarded as the dominant-negative form of MAD2 (Canman et al, 2002).
Some of the second-generation TKI like dasatinib or PKC412 have been reported to override drug resistance in Kit D816V-transformed cells (6– 8).
Depletion of the kinase by RNAi or functional perturbation using neutralising antibodies has been reported to override microtubule drug-imposed M-phase arrest and cause polyploidisation due to loss of essential Aurora B functions in the maintenance of SAC signalling and cytokinesis, respectively (Kallio et al, 2002; Ditchfield et al, 2003; Hauf et al, 2003).
A review paper in 2006 reported alert override-rates of 49%to96%6% [ 12].
It has been reported that pharmacists often override alerts generated about drug-drug interactions which they receive [ 39] and information and advice from the alerts are often ignored [ 40, 41].
Recently, reduced natural regulatory T (Tregs) cells in children with TS or OCD or both were reported, indicating a predisposition for overriding autoimmune responses [ 31].
It adds that policing "will not tolerate discrimination or victimisation or any disadvantageous treatment" against those raising concerns and says an officer "can never be deemed to bring the policing profession into disrepute" because of the "overriding duty to report wrongdoing".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com