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Generally, the studies were small in size, reported inadequately all relevant costs, uncertainties in estimates, and issues of concern and were based on limited data sources.
The majority of the methodological quality domains of random sequence generation (52.3%), allocation concealment (39.6%) and blinding (22.2%) were reported inadequately.
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Trials reporting inadequately on surrogates were not significantly more likely to recommend the intervention than trials reporting adequately on surrogates (1.93, 0.90 to 4.14).
In contrast with our hypothesis, we did not find that trials sponsored by for profit organisations or trials that recommended the experimental intervention were more likely to report inadequately on surrogates.
Trials funded by for profit organisations were not significantly more likely to report inadequately on surrogates than trials funded by non-profit organisations (relative risk 0.67, 95% confidence interval 0.40 to 1.10).
Three of the studies reported complications inadequately, and conclusions were difficult to draw.
Despite this physiotherapists have reported feeling inadequately trained to confidently use such interventions in their day-to-day practice.
A musculoskeletal problem is a common, frequently under reported, and inadequately treated condition in the older adult.
Facilities were also reported as inadequately staffed and equipped, and shortages of crucial supplies such as blood products were again apparent.
The domain most commonly noted to have improvement was allocation concealment, but the authors noted that this domain remained either poorly reported or inadequately performed in over half of the examined trials.
Unpreserved multiuse ocular solutions are at an increased risk of microbial contamination [ 1] and can potentially cause catastrophic consequences similar to those reported with inadequately preserved contact lens solutions [ 2].
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