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Similar results were also reported in the subgroup of patients with sepsis or septic shock.
At the 1-year follow-up, the relapse rate was found to be 20.5%, which is consistent with that reported in the subgroup of patients with MOH plus migraine studied by Katsarava et al. [41].
Plasma lactate levels were elevated in only five patients, and no abnormal organic acids profile was reported in the subgroup of patients with ataxia and spastic paraplegia.
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Sensitivity to chemotherapy is very low and generally reported in the small subgroup of patients with high-grade dedifferentiated chordomas with agents active in high-grade sarcomas [ 13].
A significant DFS benefit was reported only in the subgroup of women with established menopause (hazard ratio (HR) = 0.81 (95%% confidence interval (CI): 0.69 0.95)), while a potential detrimental role of adjuvant BPs was observed in premenopausal and perimenopausal women.
A randomized phase III study reported that, in the subgroup of ALK-rearranged NSCLC, patients treated with crizotinib showed higher response rate and longer progression-free survival (PFS) compared with those treated with the standard second-line chemotherapies (docetaxel or pemetrexed) [ 14].
Accordingly, only a minor change on the EQ VAS and no change on the EQ-5D Index were reported in the no change subgroup of the EORTC QLQ-C30.
As for other low-grade neoplasms, sensitivity to chemotherapy is very low and generally reported in the very small subgroup of patients with high-grade dedifferentiated chordomas with agents active in sarcomas [ 13].
Two trials [ 28, 29] reported 30-day mortality and the 28-day mortality was reported for the subgroup of ARDS patients in the SAFE study.
These figures are similar to the 100% accuracy rates reported in a subgroup of 200 women, for whom medical records could be obtained, participating in the Nurses Health Studyy.
Interestingly an accumulation of 2HG higher than the background was also reported in a subgroup of human wild type IDH gliomas [ 22].
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