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However, overall compliance with dosing in Trial 2 was similar to the compliance reported for Trial 1 (<1% of doses missed for both studies) and the six Trial 2 subjects with undetectable adduct concentrations did not report any missed doses.
Similar(59)
On the one hand, a sequential congruency effect (SCE) has been reported for trials in which participants expect a repetition of conflict level.
Similar higher risks were reported for trials using lower intervention doses.
Our trial lasted for 52 weeks and the withdrawal number from the review was reported for trials lasting approximately 26 weeks on average.
Ethical approval was more likely to be reported for trials in which clustering was accounted for correctly in the sample size calculation (OR 6.17 (95% CI 0.76 to 50.73)) and in the analysis (OR 2.66 (95% CI 0.78 to 9.03)).
Continuous measures of urinary cotinine creatinine ratio and breath CO were reported for one trial, 19 but the results were not compared between allocated trial groups.
The value of measured Physico-chemical parameters reported for each trial is the mean of duplicate.
The continuous data was reported for each trial arm as mean, standard deviation (SD) and group size.
All possible adverse events that could affect patients will be monitored and reported for every trial by the participating researchers.
The percentage of participants not providing primary and secondary outcome data at each of the follow-up stages will be reported for each trial arm.
All SAEs will be reported for the trial and if there is sufficient power to assess intervention differences, a general linear model (see above) will be conducted.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com