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The structures of 1 and a previously reported compound illustrate an interesting type of supramolecular isomerism.
Herein, we disclose a detailed effort to modify the previously reported compound 1.
These compounds were designed through an in-silico fragment growing approach based on our previous reported compound, S47 (1).
The spectral data of eusynstyelamide A (226) was similar to previously reported compound eusynstyelamide from a Fijian Ascidian E. misakiensis [129], remarkably, the compound showed opposed specific rotations.
In the present study, structural modification of the previously reported compound 4MS leads to two novel fluorescent HDAC inhibitors, 6a and 6b.
The reported compound could be considered as one of the smallest cyclic peptides (MW = 510) interfering with VEGF165/NRP-1 VEGF165/NRP-1nted up to now.
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The reported compounds can be reversibly reduced up to the trianionic state.
Therefore, it is unclear if any of these reported compounds are present in heartwood.
The reported compounds were designed as bioisosteric analogues of GABA semicarbazones.
The activity of the reported compounds warrants further optimization as novel members in cancer treatment protocols.
Previously reported compounds 1 3 were potent human KLK7 inhibitors; however, they did not exhibit inhibitory activity against mouse KLK7.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com