Addiction to injection or inhaled drugs has also been reported as associated with TB in the homeless (4 ), but this association remains debated (7, 23 ).
For some genes highlighted in our study, some variants not primarily herein studied have been reported as associated with SSc or as having a trend for association with SSc.
The TYK2 gene was reported as associated with SLE in the same study that revealed the association for IRF5 [ 69].
Of the 11 SNPs in LD with a haplotype reported as associated with SLI (Villanueva et al. 2011) we found association approaching significance with one: rs1371463 [minor allele β =−0.04 (SE 0.02), P = 0.08] in SVOPL.
Omphalomesenteric remnants and malrotation are reported as associated anomalies in SID.
Factors that have consistently been reported as associated with radiographic OA progression are obesity, generalized OA, alignment and synovitis.
Variables related to mental functions were generally reported as associated with PSDs, and in some cases these variables are PSDs themselves.
For CDKAL1, CDKN2A/2B, IGFBP2, HHEX and EXT2, we studied more than one polymorphism because they have all been reported as associated with T2D in previous studies [2] [5].
To test for shared effects down-stream of DISC1, the same global analysis was performed on other members of the DISC1 pathway for which variants had previously been reported as associated with schizophrenia or related psychotic traits in European cohorts.
Table 4 displays the results for all the SNPs with a significant association signal in at least one "detection sample" and for the SNPs repeatedly reported as associated with VEGF serum levels or correlated phenotypes in the literature.
Briefly, candidate SNPs were selected if they had a minor allele frequency greater than 5% and were located in a putative functional region of the gene (promoter, untranslated regions (UTR) or exons) or had previously been reported as associated with cancer or an inflammatory disorder.
