While evidence for such "epigenetic dysregulation" is increasing, many of the reported alterations await independent replication.
David et al. (2005) reported alterations in lactate and succinate dehydrogenises activity in L. rohita upon fenvalerate exposure.
Our laboratory has previously reported alterations in mitochondrial morphology and proteomic make-up during type 1 diabetes mellitus, with mitofilin being significantly down-regulated in interfibrillar mitochondria (IFM).
In this context, many studies reported alterations on relative water contents of various crop plants depending on the duration of applied drought (Alexieva et al. 2001; Bai et al. 2006; Keyvan 2010; Saeidi and Zabihi-e-Mahmoodabad 2009).
Several studies reported alterations in DNA cytosine methylation and histone methylation at specific genes and promoters in postmortem brain of subjects with schizophrenia, often in conjunction with changes in levels of the corresponding RNAs.
Previously, we have reported alterations in ABH antigens on the red blood cells of 55% of patients with myeloid malignancies.
Farbrother, et al., recently reported alterations in the transcriptome that occur during L. pneumophila infection under similar conditions [55].
Indeed, patients treated with the KIT antagonist imatinib mesylate (Gleevec) reported alterations in taste perception [48], [49].
However, because of the reported alterations in IL-8 levels after AZT treatment [31], we evaluated whether IL-8 secretion correlated with the mRNA findings.
During the course of our investigation, Tunquist et al generated an AKAP5 KO and reported alterations in PKA localization, hippocampal LTD, AMPAR rundown, M-current suppression, and several behavior tasks [64].
The presence of aSyn in PDAC has not been reported in the literature and previous mouse/drosophila models for this protein have not reported alterations in pancreas function or incidence of pancreatic cancer [43], [44], [45].
