The 5ive-year results of DLCST alone reported a significant higher rate of cancer in the screening group and a nonsignificant higher lung-cancer and global mortality rate in this arm but with evident lack of power.
We previously reported a significant heart rate reduction in patients with catecholamine-induced tachycardia after high-risk cardiac surgery treated with ivabradine [ 8].
While one might conclude that CB should be the preferred method based on this study, they also reported a significant higher rate of bleeding complications in the CB group.
Eight of 14 studies found a reduction in fallers (statistically significant in five), and nine of 14 reported a significant reduction in rate or number of falls.
Since the introduction of PEIT for thyroid cysts in clinical practice, some groups from Italy [ 15– 18], Denmark [ 7] and South Korea [ 19, 20] reported a significant high success rate (more than 80%%) with no significant side effects.
The prospective RCT by Evenepoel et al. [ 16] comparing efficacy and safety of heparin-coated AN69ST membranes and RCA with (RCA3.0) and without (RCA0) a calcium supplemented dialysate reported a significant higher clotting rate necessitating premature termination of the dialysis session while using a heparin-coated AN69ST membrane compared to RCA3.0 and RCA 0 (39%, 13% and 0% respectively).
Jain and colleagues also reported a significant decline in rates of healthcare-associated MRSA infections in the largest prospective observational trial to date, with the implementation of an MRSA bundle in ICU and non-ICU settings across the United States [ 22].
Two intergroup trials reported a significant 60-day mortality rate with the IFL regimen, leading to the description of both a gastrointestinal syndrome and a vascular syndrome.
None of trials reported a significant steroids-related increased rate of infection or recurrences.
Powell et al. [ 38] reported a significant reduction in the rate of unscheduled doctor visits for asthma and oral corticosteroid use in patients receiving FeNO-guided management.
