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A previous attempt at comparing the differences in in vivo and in vitro potency of olcegepant and telcagepant [40] reported a large difference in doses needed for in vivo and in vitro effect.
They reported a large difference in called variant sets among algorithms.
Three trials showed a moderate difference in ES between active treatment and sham on primary end points (ES ≥0.5) but no trials reported a large difference.
We have previously reported a large difference in prevalence of vegetarians (+23 percentage points) among the pregnant women in MoBa who frequently ate organic food compared to those who did not [ 22].
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We report a large difference in the dispersal behavior between our natural isolate (NI) and CS from a chamber containing food to a second chamber containing no food, and a subtle difference in dispersal from chambers containing only water (Fig. 9).
Previously we reported a large allele frequency difference at ABCG2 rs2231142 and heterogeneity in association with gout between Eastern (EP) and Western (WP) Polynesian sample sets [ 30].
In addition in this study women reported a larger pain area, although the difference between sexes was smaller and did not reach significance.
It has been reported that there was a large difference in etching rates between different polytypes of SiC [20].
For TNFα and IL1β, one 11 of two studies reporting overnight variations had a large difference between concentrations at the start and at the end of the 24-h measurements (that should be similar in circadian variation) and so may not have been true biological variation.
The largest effect was reported for personal control indicating a large difference in perceived personal control between the illnesses.
Consistent with previous reports, the level of coverage makes a large difference and some of the biggest disagreements are in the D. simulans experiments where 1 biological replicate has ~5 million reads where the other biological replicates had ~28 million reads.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com