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This aspect appears to be reflected in the prevalence of bone fracture and osteoporosis in the Discovery sample; despite some concordance between the two phenotypes (P-value (χ2 test) < 0.001), only 9.2% of the individuals reported an osteoporosis diagnosis, while 25% reported a bone fracture.
However, patients who initiated therapy 2 years or more following diagnosis were more likely to have reported a bone crisis around the time of initiation of treatment (16%, n = 123 of 772) compared to those in the <2 years group (6%, n = 35 of 607).
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Several authors reported a normal bone marrow MR signal in patients with leukaemia, in patients with early stages of bone marrow invasion by lymphoproliferative diseases and even in up to one-quarter of patients with stage III MM [24, 33].
Several authors reported a normal bone marrow MR signal in patients with leukemia, in patients with early stages of bone marrow invasion by lymphoproliferative diseases and even in up to one-quarter of patients with stage III multiple myeloma [ 40].
Li et al [ 4] reported a trabecular bone loss of 17% in osteoporotic femoral heads, while a 60% increase was observed in patients with OA.
Limited published data reported an altered bone metabolism in case of prolonged ICU stay [1] and a decreased in bone mineral density (BMD) in the year following ICU admission [2].
Another study reported an increased bone resorption rate (27.9 %) on pre-operative radiation therapy patients after non-vascularized iliac bone graft [15, 16].
They reported an initial bone resorption of 1.01 mm for immediate implants within the first year, which is similar to the results found in this study.
In terms of BMD, the same group reported an annual bone loss of 2.17 and 2.72% at the spine and hip, respectively (Lonning et al, 2004).
We have previously reported a decrease in bone formation markers and a dramatic increase in bone resorption markers.
Previous studies in adults' intensive care patients reported a decrease in bone density during hospitalization [9 11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com