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All analyses presented in this report were conducted using the intent-to-treat population.
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One such experiment we report was conducted using the FlexX docking algorithm on a variety of data sets containing COX-2 inhibitors as well as randomly selected inactive molecules which were docked into the COX-2 crystal structure to test the predictive power of scoring functions available in either FlexX or CScore.
Validation of self-report was conducted using hair samples.
The data analysis and statistics reporting was conducted using SAS V.9.2 (SAS Institute).
The primary pooled analysis of all the reports was conducted using the Generic Inverse Variance method using random effects weighting 57 where the log RRs for cohort studies or log ORs for case control studies were weighted by the inverse of the variance to obtain a pooled RR estimate.
In that report, a case control study was conducted using five ANKH SNPs within the coding region and flanking splice sites and three known promoter variants.
A pre and post study was conducted, using self-report, self-administered questionnaires.
The study was conducted using preferred reporting items for systematic review and meta-analyses PRISMA guidelines, flow diagram, and checklist [ 8].
The study was conducted using Standards for Reporting of Diagnostic Accuracy (STARD) principles.[15] We established an internet-based scan reading tool (www.neuroimage.co.uk) to maximise the number and range of observers and scans as described previously.[10] Brief details of key study methods are given here.
The study was conducted using lab mice.
All 113 experiments reported here were conducted using this panel, the self-reported demographic composition of which is reported in Table 2.
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