They proposed six phases: Initiation (rough concept), Pre-production (creation of game design and prototype), Production (formal details, refinement, implementation), Testing (bug reports, refinement testing, change requests), Beta (third-party testers), and Release (public release).
The FlexPepDock ab-initio protocol uses our previously reported refinement protocol [26] as a sub-module, but significantly extends its scope thanks to a preceding low-resolution peptide ab-initio sampling step.
In this work, we report the refinement of copolymer design and extend our physiological studies to demonstrate that the polymers: 1) reduce both shear stress and pressure-mediated increase in hydraulic conductivity, 2) reduce nitric oxide production in response to elevated hydrostatic pressure and, 3) reduce the capillary filtration coefficient (Kfc) in an isolated perfused mouse lung model.
In this study, we reported the refinement of one of the critical deletion regions in OT to 1p36.31 36.32 and the mapping of two contiguous minimally deleted regions, in which there are only eight genes annotated.
In this article, we report further refinements to obligate heterodimer variants of the FokI cleavage domain for the creation of custom ZFNs with minimal cellular toxicity.
Sass et al illuminated lipidic cubic phase crystals of wild-type bacteriorhodopsin at room temperature to capture the M intermediate, and reported a refinement in which they assumed that only a third of the molecules in the crystal are converted.
Attention to reporting of Refinement in AR is shown in Table 1.
Subsequent publications have reported several refinements to the generic measure.
ENM contributed in various ways in the work reported in this paper including; refinement of research problem and methodology, development of tools, data analysis, inputs to various versions of manuscript, editing and approval of final version.
FM contributed in various ways in the work reported in this paper including; refinement of methodology, data collection, data analysis, inputs to various versions of manuscript, editing and approval of final version.
This paper reports on the refinement of the descriptive system for the draft instrument (the Child Amblyopia Treatment Questionnaire, CAT-QoL) using qualitative and quantitative methods.
