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Studies were excluded based on: 1) ROI analysis; 2) no report of coordinates; 3) no formal statistical comparison; and 4) less than 10 subjects.
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In order to track points 1 and 2, the two points were marked with a single pixel and the move of the pixel was measured in ∼100 successive frames using ImageJ to report the coordinates of each selected point.
This expectation is confirmed in the difference maps derived from all three sets of coordinates reported for the K intermediate state (Figs. 5A C) [28] [30].
Functional connectivity (partial correlation coefficients) of spherical ROIs of 4 mm radius, centred on a bilateral selection of coordinates reported by Libby et al. (2012) to 4 EC subregions in both hemispheres.
The peak regions are reported as a pair of coordinates, ranging from 1 bp to >5000 bp wide, often accompanied by a score and the position at which the read frequency local maximum is observed.
For the four populations in the Jewish data set, we report the coordinates of Ashkelon, Israel, where sampling took place (Kopelman et al. 2009).
However, we find that in many cases, the data allow us to refine the breakpoint region, and that significant information is lost when only a single pair of coordinates is reported for an inversion.
Among them, NF- κB has been reported to coordinate the activation of a large network of chemokines and cytokines in the kidney following CP injection.
Many of the Rab proteins that are localized on distinct compartments have been reported to coordinate sequential steps of membrane transport [20], [21].
This algorithm aims to identify areas showing a convergence of reported coordinates across experiments, which is higher than expected under a random spatial association.
One pathologist and one radiologist (who supervised the CTp study) jointly performed the processing of all surgical specimens and reported the coordinates of the slice analysed on CTp images.
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