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Herein we report elaboration of SAR around this hit as well as the syntheses and evaluation of a hundred oxazoline- and oxazole-containing compounds derived from an efficient three step process: 1) formation of β-hydroxy amides with serine or threonine; 2) cyclization to afford oxazolines; and 3) dehydration to give the corresponding oxazoles.
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Interestingly, in LASP-1 knock out mouse embryo fibroblasts, reported elaboration of several chemokines including CXCL1 might also occur in LASP-KD5 cells [47].
This study is the first reported elaboration of small-molecular-weight fragments against this challenging target.
We report the elaboration of new l-Proline functionalized superparamagnetic iron oxide nanoparticles that can act as a new enantioselective organocatalyst.
In this work we report the elaboration of a family of metamagnetic shape memory alloys with composition Mn49Ni42-x FexSn9 (x = 0, 2, 3, 4, 5 and 6 at.%) and the systematic study of their structure, martensitic transformation (MT) behavior and functional characteristics as a function of the Fe doping and magnetic field, up to 12 T.
Readers are referred to the CONSORT PRO Extension for further information on the rationale for each item, examples of reporting and elaboration of the existing CONSORT 2010 statement in relation to PROs [ 11].
"There are a lot of explosions in the other cities," the report read, without elaboration, "and the brothers are taking up these operations".
Within the framework of orthosteric G protein coupled receptor (GPCR) polypharmacology herein we report the systematic elaboration and thorough evaluation of a data matrix generated by sampling the chemical space around a common 5,6-fused bicyclic heteroaromatic template applying characteristic pharmacophore elements of central nervous system (CNS) relevant aminergic GPCR ligands.
To best understand and apply the recommendations contained within the statement, we encourage readers to access the Explanation and Elaboration Report [ 21].
Since 1995 and the first report of the elaboration of a high-throughput system monitoring the expression of many genes in only one experiment by Patrick O Brown, the published papers based on this technology have proliferated.
This work reports the successful elaboration of egg white protein/montmorillonite clay nanobiocomposites obtained by thermomechanical processing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com