Since all patients for whom an AE was reported discontinued the study, it is probable that AEs that did not lead to treatment discontinuation were not reported by the investigators.
Of these, 61% reported that the medication review program was "very" or "somewhat useful". Thirty-five pereportedportediscontinuingng unnecessary medications, and 23% reported decreasing the frequency of dosing.
Two (5.7%) participants in the VivaGel® arm prematurely discontinued themselves from study product due to concerns with symptoms; one reported discontinuing study product due to gross hematuria after taking 14 doses, and the other reported discontinuing study product due to pain during last product insertion, cramping and gel leakage after taking 22 doses (Table 2).
We measured adherence by weekly parental report using a diary, with non-adherence defined as carers reporting discontinuing the intervention within two weeks of trial start.
Of the 1,662 participants reporting CGM use at enrollment into the registry, 675 (41%) reported discontinuing CGM use at the 1-year data collection.
Even the two largest clinics in the United States reported discontinuing diet for all patients at 3 and 5 6 years of age without any intention to change their practice.
Among the intermediate group, 14 (14%) reported discontinuing prophylaxis and restarting at least once, but they were not taking antibiotics at the time of the interview.
Among the 102 workers classified as intermediate, 40 (39%) reported ever reducing the dosage, 65 (64%) forgot to take at least one pill the previous day, and 48 (47%) reported discontinuing prophylaxis and restarting at least once.
Notably, several participants reported discontinuing CAM intermittently and continuing with conventional therapy alone because they did not wish to incur the risks of using CAM at the expense of conventional treatment.
PID 08: provider A patient who did not think that HIV existed or that he was HIV infected also reported discontinuing treatment because he did not feel that it was always necessary.
Of the 1,120 respondents who reported discontinuing antimicrobial prophylaxis because of adverse events, at another point in the interview 16% said that they did not have any adverse events.
