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Only one trial did not report allocation concealment [ 20].
Schulz and colleagues have documented that only about a third of reports of RCTs adequately report allocation concealment [ 7].
Out of 67 RCTs, 25 (37.3%) failed to report sequence generation, 35 (52.2%) failed to report allocation concealment and 36 (53.7%) did not report blinding.
In one of these studies involving 98 RCTs, 55% failed to report allocation concealment and from 25%to96%6% did not report blinding status (e.g., for participants, data analysts) [ 5].
For pneumonia two trials failed to report allocation concealment [ 29, 32] and blinding was only achieved in the trials comparing cotrimoxazole versus amoxicillin, likely due to practical limitations related to the nature of the interventions in the other trials (e.g. comparisons between injectable versus oral treatments [ 25, 27, 28]).
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All studies reported allocation concealment, therefore, we judged these studies as having low bias.
All RCTs described the procedure of randomization and blinded participants and researchers, and all trials reported allocation concealment and blinding of outcome assessment.
Gohel 2007 reported allocation concealment was inadequate.
Only one of the RCTs reported allocation concealment [ 38].
Seven reported allocation to conditions by an independent party.
All trials used appropriate methods of randomization (computer generated) and reported allocation concealment.
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