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In terms of reliability, the manufacturers report a coefficient of variation (CV) of 3.2% and 2.6% with lactate standards of 2 and 11 mmol·l−1, respectively.
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Using the 'COLD®' system, Zeravik et al. [ 51] reported a coefficient of variation of about 8%.
Two studies reported a coefficient of variation; Glaysher et al. [ 41] reported CoV=2 %=0.02 for TaqMan arrays and Hartmann et al. [ 57] reported CoV=0.2 for their custom microarray.
In an assessment of intra-individual day-to-day variations in creatinine excretion rate in 24-h urine collections based on several studies, Garde et al. [ 48] reported a coefficient of variation of 9 24%.
In the reported literature, a coefficient of repeatability of 20 40% is typical.
RDW is reported as a coefficient of variation (percentage) of red blood cell volume.
This measurement technique has been used in multiple clinical studies, and its accuracy and reliability were reported with a coefficient of variation of less than 5% [ 19– 219.
They report a generalizability coefficient of 0.85 and a dependability coefficient of 0.83 (one rater within each unit).
Our findings are consistent with a recent report using a similar next-generation sequencing platform as ours to compare RNA from paired FF and FFPE tissue from a variety of tumor types to report a correlation coefficient of 0.90 [ 14].
Regarding the reproducibility of the FMD measurements using this system, the correlation coefficient between the two examinations was reported to be 0.86 with a coefficient of variance of 11.2%.
In one study, Thorstensen et al. 22 averaged M-mode excursion measurements in four points (septal, lateral, inferior and anterior wall) and reported 4% mean error and a coefficient of repeatability of 1.6 mm.
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