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The time course for synthesis of the NDV L gene at 0, 3, 6, and 10 hours post infection (Supplementary Figure S1C) showed significant NDV genome replication well before the half-maximal expression level of IFNB1 was reached.
Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus).
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Such cell lines provide important tools for studying basic aspects of HBV replication as well as for drug discovery.
The RdRp is predicted to play a key role in genome replication, as well as in synthesis and amplification of additional subgenomic RNA.
The study provides an effective method for investigating virus replication as well as the virus host interactions in the silkworm larvae using dsRNA.
This system provides a new approach for the study of mechanisms of HBV replication as well as for the potential treatment of HBV infection.
DNA gyrase in Klebsiella spp., encoded by gyrB2 gene, is a prokaryotic type II topoisomerase which is required for DNA replication as well as to maintain the cell viability (Nitiss 2009; Gore et al. 2006).
Pentose phosphate pathway can be upregulated to increasing the amount of NADPH and ribose-5-phoshate, which are used for energy generation and DNA replication, as well as counteracting proportion of ROS for protecting cancer cells from oxidative stress.
Anti-viral therapy applies nucleoside analogs and interferon-alpha and targets viral replication as well as anti-viral immune responses, i.e. activation of T cells and modulation of innate immune cells [10].
Future work includes developing reliable distributed applications on top of the proposed IFDS, including State Machine Replication, as well an atomic broadcast service, both of which also rely on consensus.
This paper presents the methodology for conducting controlled experiment replication, as well as, results of a controlled experiment and an internal replication that investigated the effectiveness of intelligent authoring shell eXtended Tutor Expert System (xTEx-Sys).
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