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First, the reason for replication was that the two included trials of greatest weight also fulfilled Cook and colleagues' criterion of overt bleeding [ 12].
Although this meant mixing males and females together, the advantage of using the whole sample for the Stage 2 replication was that it provided greater power to detect effects.
One idea that was briefly favored for the epigenetic inheritance of post-translational histone modifications through replication was that the parental H3-H4 22 tetramer may be split into two H3-H4 dimers [ 21].
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In contrast to targeting a single step of HIV-1 infection, the advantage of inhibiting a number of critical steps in virus replication is that complete and effective suppression is more likely to achieve.
The easy story to tell based on failed replications was that "science is broken," Nosek says, but the most prominent coverage "did not shy away from the complexity.
One of the key properties of deferred update replication is that read-only transactions can be executed by a single server, without communication across servers.
One criterion for replication is that the follow-up sample should be a random sample drawn from the same population as the discovery sample [26].
The challenge with epistatic replication is that there are many factors that influence whether the interaction can be detected in a given data set.
One major limitation of the use of the Ki67 promoter to regulate adenovirus replication is that it is not always active in melanoma.
Another possibility for inheritance of histone modifications through replication is that the parental histones carrying the histone-modifications may be reassembled back onto the same DNA sequences on the newly-replicated DNA molecules that they occupied on the parental DNA.
One example of a study with both spatial and temporal replication is that by Conner (1989) who studied DDS on horn length in male Bolitotherus cornutus (fungus beetle) populations of naturally and experimentally varying densities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com