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Data-sharing is an essential tool for replication, validation and extension of empirical results.
The studies were subject to intensive replication, validation, and reanalysis that confirmed the original findings.
Second, a replication validation phase to corroborate results from the previous steps.
The original studies were subject to intensive replication, validation, and re-analysis which confirmed the original findings [ 84].
Solid association studies would ideally use at least two large independent pairs of case and control cohorts, one employing a test sample and a subsequent replication (validation) sample.
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Taken all these limitations into account, it is critical to stress that this is a pilot study that needs further replication and validation as finding biomarkers from the identified differentiating significant compounds still requires optimization of target-specific analytical methods and validation of these methods with their reference materials and proficiency tests [50].
Our objective will be addressed in aims 1) identification of miRNA and proteomic signature in sALS and fALS progression; and 2) replication and validation of the identified hits.
With replication and validation of this effect, MMN may prove to be an important indicator of a common psychopathology shared by a significant proportion of individuals with schizophrenia and bipolar spectrum illnesses.
The lack of replication and validation studies from genome-wide association studies in general and specifically with infectious diseases, including STIs, is a continuing problem that limits the utility of these studies.
Tissue homogenates were obtained as previously described [10] from the same ICH patients included in the replication and validation studies that table 1 indicates.
As the majority of IIS mutant mouse aging studies are based on lifespan curves derived from single experimental cohorts, several authors (e.g. [13], [14]) have suggested that replication and validation of these experiments is necessary in order to use these models with confidence in our quest to understand the aging process.
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