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Single replication trials are standard procedure for determination of flowering time due to the high heritability.
There were many individual studies with diverse methods and very few replication trials.
Many efficacy and replication trials have not provided any information on enrolment rates amongst eligible participants [ 12, 58- 65].
With these positive results, investigators began replication trials in Bangladesh, Pakistan, and later, in Tanzania and Zambia.
The missing data and many of the methodological issues debated here are now made much clearer in the replication trials.
Due to the trial design the pooled estimate that Miguel and Kremer prefer contains a non-randomized before and after comparison, as clarified in the replication trials.
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To address this skepticism, the district health management team (DHMT) from the Nkwanta District of the Volta Region launched a replication trial of the Navrongo experiment [ 3].
A large replication trial was conducted in rural Ghana, in an area where the consumption of red palm oil is common, with the stated objective of disproving that vitamin A supplementation could reduce maternal mortality [ 26].
An expert consultative meeting convened in Washington, DC shortly after completion of the Nepal trial concluded that, prior to any changes in policy, at least one replication trial in South Asia would be necessary to expand the evidence base for chlorhexidine cleansing of the cord[ 9].
Nodal support was estimated with a bootstrap procedure with 100 replications and 10 replicate trials of sequence addition.
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