Replication of this result is desirable since correction for population structure was inadequate: only a single SNP was used to correct for population structure.
Replication of this result in an independent cohort is needed.
As ORCs are found on chromatin in G1 (before DNA replication begins) this result was not unexpected.
Replication of this result has been attempted in multiple studies, with some studies confirming an association [ 3, 4, 6- 13, 21] and some others not finding it [ 3, 4, 6- 13, 21].
However, despite many studies, replication of this result has been mixed, with an approximately equal amount of work reporting positive (e.g. Ashley-Koch et al, 2007; Holt et al, 2010; Serajee et al, 2006) and negative (e.g. Bonora et al, 2003; Dutta et al, 2008) results, as well as tantalizing evidence from one GWAS (Anney et al, 2010).
Although our findings at GJA5 are statistically significant (P = 0.01), do not require correction for multiple comparisons and are highly biologically plausible, replication of this result in a similarly large and ethnically homogeneous population of TOF patients will be of importance in due course.
Stein et al. (2009) recently reported a higher frequency of the homozygous 'LL' allele of the 5HTTLPR in a group of undergraduate students with high scores on trait resilience as measured by the Connor-Davidson Resilience Scale (CD-RISC) (Connor and Davidson 2003), but the authors duly emphasize the necessity of replication of this result.
Replication of this result is needed but future prospective studies would need to be extremely large and to follow participants for long periods (e.g., a cohort of 500 000 people followed for a decade) to have sufficient power to examine the association between organic food consumption and non-Hodgkin lymphoma.
The osrecql4-2 mutant failed to recover from DNA replication arrest; this resulted in an increased number of DSBs requiring repair, possibly by HR.
However, as our replication analysis shows, this result changes over time.
