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With replication, the findings of this study are clinically valuable since they can be used to identify a subgroup of people with bipolar disorder (those with a history of childhood maltreatment) who are at risk of poor health (Post et al. 2013) and worse clinical course (Agnew-Blais and Danese 2016).
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The consortia provide the opportunity to prospectively plan meta-analyses and find independent studies for replication of the findings (Psaty and Hofman 2010).
Replication of the findings in future studies of larger sample size is warranted.
Although sensitivity to smaller sample sizes was restored by the process of weighing, the impact of the mean effect would validate the replication of the findings more significantly by being computed over a larger study pool.
For both depression and schizophrenia, monoamine-related markers have been studied with only partial success in terms of specificity of the marker, or replication of the findings.
Replication of the findings in large, well-powered independent samples is crucial if this problem is to be overcome, and will likely require a multicenter collaboration.
Despite these limitations, the analysis gave a striking replication of the findings on neurological conditions [1], namely that, when prevalence is taken into account, the number of publications on rare conditions is greatly in excess of that for common conditions.
Therefore, a positive replication of the findings by Mencía et al. is still lacking.
Thus, replication of the findings using other informants could prove interesting.
Replication of the findings of previous research is thus an important task.
However, replication of the findings in independent cohorts will be necessary to fully exclude this possibility.
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