Exact(32)
Grey lines indicate the expected mean for each parameter set with no selection (deficit of zero); the black line shows the mutation rate in one replication step, and therefore the expected frequency when mutants cannot replicate.
This probably occurs due to the replication step.
This replication step differs in RNA and DNA viruses, but mRNA is produced in all.
The inhibition of compound to viral transcription and replication step usually works at viral protease or polymerase activity.
We have also excluded the possibility that both inhibitors act at the replication step of virus life cycle.
We considered a total advantage of 1.1-, 2-, or 10-fold in each genome replication step for the full set of respiratory droplet transmission enabling substitutions (table S2 and fig. S6) (A twofold advantage at each genome replication step translates into an approximately 100-fold increase in mutant virus titer after 36 hours).
Similar(28)
The results of HCV ssRNA in situ hybridization and dsRNA immunofluorescent staining showed that HCV genome started to replicate as early as 12 hpi, and accomplished its genome replication steps steadily throughout the course of infection.
There are several key features shared by novel anti-HSV drugs, from currently available optimized drugs to small molecules able to interfere with various virus replication steps.
Preliminary characterization of its inhibition mechanism ruled out direct inactivation of the virus (virucidal effect) or interference with early viral replication steps.
Although mutations can be introduced at any of these replication steps, reverse transcriptase (RT) errors play a major role in retroviral mutation.
We reanalyzed the discovery sample KORA S3 and the data from replication steps by subdividing individuals into normal weight (BMI<25 kg/m2) and overweight (BMI≥25 kgroupsgroups (Table 3).
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