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Since Mtb's proteome differs qualitatively and quantitatively during bacterial replication stages from that expressed during dormancy, improved TB vaccines should drive immune responses to Mtb antigens expressed during multiple stages of infection.
Significant genome-wide signals (p≤5 × 10-8) were tested for replication in an independent GWAS of 30 770 cases and 286 913 controls, followed by a joint analysis of the discovery and replication stages.
Significant evidence of replication was observed, and both SNP markers surpassed the formal threshold for genome-wide significance upon meta-analysis of both discovery and replication stages (P = 5.79 × 10 -10 10 -10allele odds ratio (OR) = 1.26 for rs13382811 and P = 2.01 × 10(-9), per-allele Oratio.79 fOR rs6469937).
None of the SNPs reached this level of significance in either the discovery or replication stages.
The IPNV replication stages can be divided into early (6 h post-infection (p.i .), middle (12 h p.i ., and late replication stages (24 h p.i). in the ZF4 cell system.
We hypothesized that TNFα plays a crucial role in regulating either the apoptotic or necrotic cell death pathway at different replication stages.
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Let the significance level of the discovery stage be α D, which means that markers with P(1) < α D are selected and replicated in the replication stage.
The inhibition of pathogenic bacteria at the replication stage is important to halt their further reproduction and spread.
We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage.
A total of 554 men from the Korean Cancer Prevention Study-II were used as a discovery stage and 1575 men collected by the Korean Genome Epidemiology Study were used as a replication stage.
The study comprised case materials from five European countries, 2,731 migraine cases were included in the discovery stage and 3,202 in the replication stage.
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